Bioactive Small Molecules
AdipoGen 3,3'-Diethylthiacarbocyanine iodide (250 mg)
Chemical. CAS: 905-97-5. Formula: C21H21IN2S2. MW: 492.44. Synthetic. DiSC2(3) is a light-sensitive cyanine dye. Spectral data: Absorption: lambdamax 560nm (MeOH). Cyanine dyes are commonly used for photographic sensitisation, dye lasers and fluorescence microscopy. A different salt form of Thiazole purple (bromide salt). DiSC2(3) has been shown to bind to PNA-DNA complex and accelerated photobleaching can be used for diagnostics purpose. It has been used as an acceptor dye in electronic excitation energy transfer (EEET).
AdipoGen Shogaol (10 mg)
Chemical. CAS: 555-66-8. Formula: C17H24O3. MW: 276.37. Shogaol is a pungent bioactive component of ginger (Zingiber officinale Roscoe) with anti-inflammatory, anticancer, antioxidant, neuroprotective, antidiabetic, cardioprotective and antimicrobial properties. The anticancer activity is associated with the induction of apoptosis in cancer cells through the production of reactive oxygen species and the activation of caspase, impairment of tubulin polymerization, downregulation of STAT3 and NF-kappaB signaling, inhibition of the expression of inflammatory mediators and suppresseion of Toll-like receptor signaling. It also has been shown to induce autophagy and activate peroxisomal proliferator activated receptor gamma (PPARgamma). 6-Shogaol can also activate both TRPV1 and TRPA1 channels. 6-Shogaol inhibits the NF-kappaB and NLRP3 signaling pathways.
AdipoGen Droperidol (1 g)
Chemical. CAS: 548-73-2. Formula: C22H22FN3O2. MW: 379.43. Droperidol is a butyrophenone that acts as an antagonist at dopamine receptors D2 and D4. It less potently inhibits the human voltage-gated potassium channel, 5-HT, alpha-adrenergic and histamine receptors. Droperidol has been shown to provide relief from acute migraines and prevent nausea and vomiting in clinical trials and has anti-psychotic activity.
AdipoGen Ginsenoside Rg3 (5 mg)
Chemical. CAS: 14197-60-5. Formula: C42H72O13. MW: 785.01. Ginsenoside Rg3 is a panaxadiol found in white and red P. ginseng. Show a broad range of biological in vitro and in vivo effects, including anticancer, antidiabetic, neuroprotective, antioxidant, anti-hypertensive, and anti-inflammatory actions. The anticancer mechanisms include induction of apoptosis and autophagy, inhibition of proliferation, inhibition of metastasis and angiogenesis, cell cycle arrest, immunomodulatory effects, sensitization to radiation, reducing multidrug resistance and inducing genotoxicity to the cancer cells. Ginsenoside Rg3 has been shown to inhibit the 5-HT3A and alpha3beta4 nACh receptors, the voltage-dependent Ca2+, K+, and Na+ channel currents. It is a scavenger of hydroxyl radicals and downregulated the expression of DNA methyltransferases, reducing global DNA methylation, modifying the methylation of the promoter region of some relevant genes in cancer.
AdipoGen Amorolfine hydrochloride (250 mg)
Chemical. CAS: 78613-38-4. Formula: C21H35ON . HCl. MW: 317.51 . 36.46. Amorolfine (or amorolfin), is a morpholine antifungal drug that inhibits D14-sterol reductase and cholestenol D7-D8 isomerase, consequently depleting ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membranes in vivo. It acts primarily by inhibiting ergosterol biosynthesis, a component of fungal cell membrane, and possesses both fungistatic and fungicidal activity. Its spectrum of in vitro activity includes dermatophyte, dimorphic, dematiaceous and filamentous fungi and some yeasts.
AdipoGen Forskolin (50 mg)
Chemical. CAS: 66575-29-9. Formula: C22H34O7. MW: 410.5. Forskolin is a naturally occurring diterpene. It directly activates adenylyl cyclase through its catalytic subunit and is commonly used to raise levels of cAMP (an important signal carrier necessary for the proper biological response of cells to hormones, neurotransmitters, and other extracellular signals) in a wide variety of intact cells and tissue preparations. Forskolin also interacts with glucose transporters and certain ion channels and has been used for examining adenylyl cyclase expression, regulation, and G protein signaling. Forskolin is a smooth muscle relaxant/vasodilator with inotropic and antihypertensive activity. Forskolin has antioxidant and anti-inflammatory property and reduces hyperglycemia by stimulating insulin release. It has anti-neuroinflammatory and neuroprotective properties that ameliorates Alzheimer’s disease symptoms and has also shown a number of antitumor effects.
AdipoGen 6-Chloropurine (5 g)
Chemical. CAS: 87-42-3. Formula: C5H3ClN4. MW: 154.56. 6-Chloropurine is a building block in chemical synthesis and is used as an intermediate in the preparation of 9-alkylpurines via alkylation with various substituted alkyl halides in DMSO. 6-Chloropurine based compounds have been shown to display antiviral and antitumor properties.
AdipoGen Acridine Orange hemi(zinc chloride) (100 g)
Chemical. CAS: 10127-02-3. Formula: C17H20ClN3 . HCl . 1/2ZnCl2. MW: 369.96. Acridine Orange hemi(zinc chloride) salt is a cell-permeable metachromatic fluorescent dye that stains DNA and RNA. It is used as a nucleic acid-selective fluorescent cationic dye useful for cell cycle determination. Being cell-permeable, it interacts with DNA and RNA by intercalation or electrostatic attractions respectively. When bound to DNA, it is very similar spectrally to fluorescein, with an excitation maximum at 502nm and an emission maximum at 525nm (green). When acridine orange associates with RNA, the excitation maximum shifts to 460nm (blue), and the emission maximum shifts to 650nm (red). Acridine orange will also enter acidic compartments such as lysosomes where it becomes protonated and sequestered. Within these low pH vesicles, the dye emits red fluorescence when excited by blue light.
Medchemexpress LLC Donepezil (E2020 free base) | 120014-06-4 | MFCD00912833 | >98.0% | 379.49 g/mol | C24H29NO3 | 5 MG
Donepezil (E2020 free base) is a reversible acetylcholinesterase (AChE) inhibitor supplied for research and analytical use. It exhibits potent AChE inhibition (IC50s reported as 8.12 nM for bovine AChE and 11.6 nM for human AChE), with molecular formula C24H29NO3 and molecular weight 379.49 g/mol.
- Potent, specific AChE inhibition useful for pharmacology studies.
- High purity suitable for analytical and research applications.
- Soluble in DMSO (~33.33 mg/mL) and formulatable in common vehicles for dosing.
- Storage stability: 4°C sealed; in solvent -80°C (6 months) or -20°C (1 month).
- Provided in small pack sizes suitable for preparing stock solutions.
Medchemexpress LLC Dacinostat | 404951-53-7 | MFCD09970778 | 98.5% | 379.45 g/mol | C22H25N3O3 | 5 MG
Dacinostat is a potent histone deacetylase (HDAC) inhibitor used in cancer and autophagy research. It exhibits low-nanomolar potency (HDAC IC50 ≈ 32 nM; HDAC1 IC50 ≈ 9 nM) and is supplied as a high-purity powder for laboratory studies.
- High potency against HDAC enzymes, enabling low-nanomolar activity.
- Supplied as a powder suitable for in vitro and cell-based studies.
- High purity (98.5%), appropriate for biochemical assays.
- Available in small research pack sizes suitable for screening and follow-up experiments.
- Stable under recommended storage conditions for long-term archival.
- Soluble in DMSO; use freshly opened solvent and aliquot stocks to avoid degradation.
- Recommended handling for in vivo work: prepare fresh working solutions and limit DMSO to ≤2% when appropriate.
Apexbio Technology LLC StemRegenin 1 (SR1), 50mg. Cas: 1227633-49-9 MFCD: MFCD16987861. AhR antagonist
StemRegenin 1 (SR1), a purine derivative, is a potent small molecule inhibitor of aryl hydrocarbon receptor (AhR) that potently antagonizes AhR with a value of 50% inhibition concentration IC50 of 127 nM in CD34+ cells. Other sizes are available. Please inqury us for quote.
Apexbio Technology LLC 3-Deazaneplanocin A (DZNep) hydrochloride, 25mg
3-Deazaneplanocin A (DZNep) hydrochloride is a selective inhibitor of ENZ2 inhibitor with IC50 value of 0.08-0.24 M [1].ENZ2 is a sub-unit of PRC2 and plays an important role in regulating cell proliferation and cell-cycle progression. Other sizes are available. Please inqury us for quote.
Apexbio Technology LLC Pancuronium dibromide, 25mg. Cas: 15500-66-0 MFCD: MFCD00079223. AChR antagonist
Pancuronium dibromide is a competitive AChR antagonist (IC50 = 5.5 nM) and acts as a skeletal muscle relaxant. Pancuronium dibromide interrupts neuromuscular transmission by competing with acetylcholine for receptor sites on the motor end-plate. Pancuroni Other sizes are available. Please inqury us for quote.
Apexbio Technology LLC Parthenolide, 50mg. Cas: 20554-84-1 MFCD: MFCD00134592.
Parthenolide is a sesquiterpene lactone and active principle of feverfew (Chrysanthemum parthenium). Other sizes are available. Please inqury us for quote.
Apexbio Technology LLC Cy5.5 hydrazide (non-sulfonated), 1mg. Cas: N/A MFCD: NA. carbonyl-reactive dye
Cy5.5 hydrazide is a reactive dye for the labeling of biomolecules containing carbonyl groups, such as ketone and aldehydes. This dye pocesses a hydrazide group that can be used to label glycans at their reducing end or other reducing sugars, forming a hydrazone linkage. Other sizes are available. Please inqury us for quote.